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It was shown that the expression of both glutamate transporters (EAAT1 and EAAT2) in astrocytes is rapidly reduced following hypoxia and ischemia, which leads to further extrasynaptic glutamate accumulation (Sheldon and Robinson, 2007

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Correspondingly, the protective effects of antioxidant supplementation have been observed in experimental models of NAFLD 15,16,17,18